pentobarbital will minimize the level or result of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
pentobarbital will reduce the extent or outcome of theophylline by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
Keep an eye on Closely (one)pentobarbital will reduce the extent or result of levamlodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will increase amounts of vortioxetine by raising metabolism. Modify Therapy/Check Intently. Look at growing the vortioxetine dose when coadministered with solid CYP inducers for >fourteen days; not to exceed 3 instances initial vortioxetine dose.
CYP3A4 inducers might increase the formation from the neurotoxic/nephrotoxic ifosfamide metabolite, chloroacetaldehyde. Closely keep track of sufferers using ifosfamide with CYP3A4 inducers for toxicities and look at dose adjustment.
pentobarbital will decrease the extent or influence of tamoxifen by impacting hepatic enzyme CYP2C9/10 metabolism. Use Warning/Observe.
With therapeutic doses of TCAs, barbiturates raise metabolism and decrease blood concentrations of TCAs.
Phenytoin and barbiturate blood ranges need to be monitored much more routinely if provided concurrently; effect of barbiturates on phenytoin metabolism documented to generally be variable; sodium valproate and valproic acid appear to lower barbiturate metabolism; observe barbiturate blood levels and make proper dosage adjustments as needed
pentobarbital will decrease the extent or impact of budesonide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
This drug could interfere with the absorption of orally administered griseofulvin, decreasing its blood ranges; effects of blood level reduction not known; preferable to prevent concomitant administration of such check here drugs
Warning with use throughout surgical procedures or processes in youngsters younger than three yr or in pregnant Girls during their third trimester
pentobarbital will reduce the level or result of amiodarone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
With therapeutic doses of TCAs, barbiturates boost metabolism and reduce blood concentrations of TCAs.
fentanyl iontophoretic transdermal method and pentobarbital equally enhance sedation. Keep away from or Use Alternate Drug. Restrict use to people for whom different treatment method options are inadequate